Examples of Recent Refereed Publications: Professor Richard O Kennedy

1. The development and validation of a surface plasmon resonance-based inhibition immunoassay for the determination of warfarin in plasma ultrafiltrate. B. Fitzpatrick and R. O’Kennedy (2003). (submitted to J. Immunol. Methods).

2. Production and characterisation of murine single chain Fv antibodies to aflatoxin B1 derived from a pre-immunised antibody phage display library system. S. Daly, P. Dillon, B. Manning, L. Dunne and R. O’Kennedy (2002). Food Agric. Immunol, 14, 255-274.

3. Development and use of immunosensors for environmental monitoring. P. Dillon, S. Daly, T. Killard and R. O’Kennedy (2003). Int. J. Environ. Anal. Chem. 83(7-8)
525-543.

4. Application of Capillary Electrophoresis with pH-mediated Sample Stacking to Analysis of Coumarin Metabolites in Microsomal Incubations. E.M. Ward, M.R. Smyth, R. O’Kennedy and C.E. Lunte, J. Pharm. Biomed. Anal., 32 (2003)
813-822.

5. Immunoassay for the determination of morphine-3-glucuronide using a surface plasmon resonance-based biosensor. P. Dillon, S. Daly, B. Manning and R. O’Kennedy (2003). Biosensors and Bioelectronics 18(2-3), 217-227.

6. Production of a recombinant anti-morphine-3-glucuronide single chain variable fragment (scFv) antibody for the development of a surface plasmon resonance-based immunoassay. P. Dillon, B. Manning, S. Daly, A. Killard and R. O’Kennedy (2003). J. Immunol. Methods., 276.151-161.

7. Advances in biosensors for detection of pathogens in food and water. P. Leonard, S. Hearty, J. Brennan, L. Dunne, J. Quinn, T. Chakraborty and R. O’Kennedy (2003). Enzyme and Microbial Technology. 32(1) 3-13.

8. Development of ELISA and sensor-based assays for the detection of ethynyl estradiol in bile. J. Fitzpatrick, B. Manning and R. O’Kennedy (2003). Food Agric. Immunol. (in press).

9. The production, purification, purification and characterisation of genetically-derived scFv and bifunctional antibody fragments capable of detecting illicit drug residues. J. Brennan and R. O’Kennedy (2003). J. Chromatography B.
18, 217-227.

10. The development of novel miniaturised immuno-sensing devices: A review of a small technology with a large future. A. Sheehan, J. Quinn, S. Daly, P. Dillon and R. O’Kennedy (2002). Analytical Letters 36, 511-537.

11. Production and characterisation of murine single chain Fv antibodies to aflatoxin B1 derived from a pre-immunised antibody phage display library system. S. Daly, P. Dillon, B. Manning, L. Dunne and R. O’Kennedy (2002). Food Agric. Immunol, 14, 255-274.

12. Determination of electrophoretic mobility distributions through the analysis of individual mitochondrial events by capillary electrophoresis with laser-induced fluorescence detection. C. Duffy, K. Fuller, M. Malvey, R. O’Kennedy and E. Arriaga (2002). Analytical Chemistry, 74 (1), 171-176.

13. The use of in vitro immunization as an adjunct to monoclonal antibody production may result in the production of hybridomas secreting polyreactive antibodies M. McMahon and R. O’Kennedy (2002). J. Immunol. Methods, 258 (1-2), 27-36.

14. Detection of whole cell:antibody interactions using Biacore’s SPR technology. J. Quinn & R. O’Kennedy (2001). BIA Journal, 1, 22-24.

15. Rapid detection systems for cancer and other clinical diseases. A. Lacey and R. O’Kennedy (2001). W. Ind. J. Med., 290, 36-46.

16. Biosensor-based estimation of kinetic and equilibrium constants. J.G. Quinn and R. O’Kennedy (2001). Analytical Biochemistry, 390(i), 26-46.

17. Use of scFv antibody fragments in analysis. R. O’Kennedy and collaborators (2001). Invited Review, Analytical Letters, 34, (11), 1799-1827.

18. Determination of properties of individual liposomes by capillary electrophoresis with post-column laser induced fluorescence detection. C.F. Duffy, S. Gafoor, D.P. Richards, H. Ahmadzadeh, R. O’Kennedy and E.A. Arriaga (2001). Analytical Chemistry, 73(8), 1855-1861.

19. The use of phosphoric acid TPB as generic immunogen in the production of broad specific anti-organo-phosphate pesticide antibody. M. Alcocer, C. Doyen, S. Garret, H. Lee, M.R.A. Morgan, P. Dillon, B. Manning, S. Daly and R. O’Kennedy (2000). J. Agric. Food Chem., 48, 2228-2233.

20. Immunology in sport – getting the balance right. R. O’Kennedy (2000). Invited editorial Br. J. Sports Science, 34(3), 161.

21. Development and application of SPR-based biosensors for the detection of cell-ligand interactions. J.G. Quinn, S. O’Neill, A. Doyle, C. McAtamney, D. Diamond, B.D. MacCraith and R. O’Kennedy (2000). Analytical Biochemistry, 281, 135-143.

22. Polyreactivity as an acquired artefact, rather than a physiologic property, of antibodies: evidence that monoreactive antibodies may gain the ability to bind to multiple antigens after exposure to low pH. M.J. McMahon and R. O’Kennedy (2000). J. Immunol. Methods, 241, 1-10.

23. Applications and recent developments in the use of antibodies for analysis. J. Fitzpatrick, L. Fanning, S. Hearty, P. Leonard, B.M. Manning, J.G. Quinn and R. O’Kennedy (2000). Analytical Letters 33(13), 2563-2609.

24. Stephen J. Daly, Gary J. Keating, Paul P. Dillon, Bernadette M. Manning, Richard O’ Kennedy, Heather Lee, and Michael R.A. Morgan (2000). Development of surface plasmon resonance-based immunoassay for aflatoxin B1. J. Agric. Food Chem., 48(11), 5097-5104.

25. Immunoassay for the determination of 7-hydroxycoumarin in serum using ‘real-time’ biosensor analysis. G. Keating J. Quinn and R. O’Kennedy (1999). Analytical Letters, 32(11), 2163-2176.

26. The use of regenerable, affinity ligand-based surfaces for immunosensor applications. J. Quinn, P. Patel, B. Fitzpatrick, B. Manning, P. Dillon, S. Daly, R. O’Kennedy, M. Alcocer, H. Lee, M. Morgan and K. Lang (1999). Biosensors and Bioelectronics , 14, 587-595.

27. Comparison of the cytosensor microphysiometer with the MTT assay for assessing compound toxicities. D. Cooke and R. O’Kennedy (1999). Analytical Biochemistry, 274, 188-194.

28. Transduction platforms and biointerfacial design of biosensors for ‘real-time’ biomolecular interactional analysis. J. Quinn and R. O’Kennedy (1999). Analytical Letters, 32(8), 1475-1517.

29. Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresis. C. Duffy and R. O’Kennedy (1998). J. Pharmaceutical and Biomedical Analysis, 17(8), 1279-1284.

30. Optical immunosensing of LDH. T. McCormack, G. O’Keefe, B. MacCraith and R. O’Kennedy (1997). Sensors and Actuators, B41, Issue 1-3, 89-96.

31. Detection of blood group antigens utilising immobilised antibodies and surface plasmon resonance. J. Quinn, R. O’Kennedy, M. Smyth, J. Moulds and T. Frame (1997). J. Immunol. Methods, 206, 87-96.

32. Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin. D. Egan, P. James, D. Cooke and R. O’Kennedy (1997). Cancer Letters, 118, 201-211.

33. Effects of acetonitrile on horseradish peroxidase (HRP) anti-HRP antibody interaction. B. Lu, E. Iwuoha, M.R. Smyth and R. O’Kennedy (1997). Biosensors & Bioelectronics, 12, 619-625.

34. The preparation of a molecularly imprinted polymer to 7-hydroxycoumarin and its use as a solid phase extraction material. M. Walsh, J. Howarth, M.T. Kelly, R. O’Kennedy and M.R. Smyth (1997). J. Pharmaceutical and Biomedical Analysis, 16, 319-325.

35. Development of an amperometric immunosensor for horseradish peroxidase (HRP) involving a non-diffusional osmium redox polymer co-immobilised with anti-HRP antibody. B. Liu, E.I. Iwuoha, M.R. Smyth and R. O’Kennedy (1997). Analyst, 34, 21-24.

36. The pH dependence of the emitting properties of ruthenium polypyridyl complexes bound to poly-l-lysine. M. Walsh, E. Ryan, R. O’Kennedy and J.G. Vos (1996). Journal of Inorganic Biochemistry, 63, 215-221.

37. The simultaneous determination of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide in human serum and plasma by high performance liquid chromatography. D.P. Bogan and R. O'Kennedy (1996). J. Chromatography Biomed. Appl., 686, 267-273.

38. The determination of the UDP-glucuronyl transferase activity for 7-hydroxycoumarin in rabbit tissue samples by HPLC. C. Duffy, D.P. Bogan and R. O'Kennedy (1996). J. Liquid Chromatography, 20(2), 217-226.